Volume 11, Issue 3 (11-2024)
J Jiroft Univ Med Sci 2024, 11(3): 1689-1698 |
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Mirdar S, Sharifi M, Zamanfar D, Pak M. The Effect of 12 Weeks of Aerobic Training on Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) Enzymes in Girls with Idiopathic Central Precocious Puberty Treated with GnRH Analogues. J Jiroft Univ Med Sci 2024; 11 (3) :1689-1698
URL: http://journal.jmu.ac.ir/article-1-793-en.html
URL: http://journal.jmu.ac.ir/article-1-793-en.html
1- Full Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran , sh.mirdar@umz.ac.ir
2- Assistant Professor, College of Skills and Entrepreneurship, Babol branch, Islamic Azad University, Babol, Iran
3- Associate Professor, Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4- MSc in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
2- Assistant Professor, College of Skills and Entrepreneurship, Babol branch, Islamic Azad University, Babol, Iran
3- Associate Professor, Department of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4- MSc in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran
Abstract: (105 Views)
Introduction: During the last decades, physical activity has become a key auxiliary tool in controling many diseases, including premature puberty. The aim of this study was to investigate the effect of 12 weeks of aerobic training on changes in the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in girls with idiopathic central precocious puberty treated with analogs.
Materials and Methods: The current research was of applied and semi-experimental type. The samples of this study were 20 girls suffering from precocious puberty who were selected by targeted and available sampling method from BoAli Hospital in Sari cit.y They were randomly divided into two groups of 10 including aerobic exercise group and treatment with GnRH agonist. The levels of AST and ALT enzymes of the research subjects before and after participating in the 12 week aerobic exercise program were measured by ELISA method. The exercise protocol consisted of 12 weeks of aerobic exercise with an intensity of 50-70% of the maximum heart rate and three sessions per week, following the principle of overload, along with GnRH agonist treatment.
Results: AST values in the experimental group decreased compared to the pre-test (p<0.001). The result of the research in ALT findings showed that 12 weeks of aerobic training and treatment with GnRH analog in the experimental group decreased ALT values compared to the pre-test (p<0.001). Conclusion: Paying attention to the serious role of sport exercise and increasing physical literacy on improving health and body composition by changing the lifestyle of childhood and adolescence can be considered as a non- pharmacological suggestion. |
Type of Study: Research |
Subject:
Medical Sciences / Sports Medicine
Received: 2024/08/3 | Accepted: 2024/11/16 | Published: 2024/11/30
Received: 2024/08/3 | Accepted: 2024/11/16 | Published: 2024/11/30
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