Volume 12, Issue 2 (9-2025)
J Jiroft Univ Med Sci 2025, 12(2): 1887-1899 |
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Homaye Razavi R, Cheragh Birjandi S, Teymoori Kheravi M, Rezaei V, Rezaeian N. A Comparative Study of the Effects of Aerobic and Combined (Aerobic and Resistance) Training on some Heart Health Indicators (MMP-2, TIMP-2, and MSTN) in Adult Male Rats. J Jiroft Univ Med Sci 2025; 12 (2) :1887-1899
URL: http://journal.jmu.ac.ir/article-1-848-en.html
URL: http://journal.jmu.ac.ir/article-1-848-en.html
Romina Homaye Razavi1 
, Sadegh Cheragh Birjandi2 , Mostafa Teymoori Kheravi3 , Vahid Rezaei3 , Najmeh Rezaeian3
, Sadegh Cheragh Birjandi2 , Mostafa Teymoori Kheravi3 , Vahid Rezaei3 , Najmeh Rezaeian3
1- Ph.D Candidate, Department of Physical Education and Sport Sciences, Boj.C., Islamic Azad University, Bojnourd, Iran
2- Assistant Professor, Department of Physical Education and Sport Sciences, Boj.C., Islamic Azad University, Bojnourd, Iran ,birjandi@bojnourdiau.ac.ir
3- Assistant Professor, Department of Physical Education and Sport Sciences, Boj.C., Islamic Azad University, Bojnourd, Iran
2- Assistant Professor, Department of Physical Education and Sport Sciences, Boj.C., Islamic Azad University, Bojnourd, Iran ,
3- Assistant Professor, Department of Physical Education and Sport Sciences, Boj.C., Islamic Azad University, Bojnourd, Iran
Abstract: (9 Views)
| Introduction: Assessment of cardiovascular disease-related biomarkers such as matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) my help predict the onset of these diseases. The present study aimed to evaluate and compare the effects of aerobic and combined (aerobic and resistance) training on specific cardiac health indicators in adult male Wistar rats. Materials and Methods: A total of 24 adult male Wistar rats (18-20 months old, 300-380 g, obtained from Razi Serum Institute, Mashhad) were randomly divided into three groups: combined training, aerobic training, and control (n=8 each). The combined training group performed aerobic exercise (treadmill running at 40-60% of maximum speed, 60 minutes) and resistance exercise (climbing a rodent-specific ladder at 40-60% of one-repetition maximum, 45 minutes) on alternate days, five days a week for eight weeksAt 48 hours following the final training session, cardiac tissue samples were obtained, and the gene expression of myostatin, MMP-2, and TIMP-2 was measured using Real-Time PCR. Data were analyzed by one-way ANOVA and Tukey’s post hoc test at a significance level of p<0.05. Results: A significant decrease in myostatin and MMP-2 expression was observed in both exercise groups compared to the control group (p<0.01). MMP-2 reduction was also significantly greater in the combined group than in the aerobic group (p<0.01). TIMP-2 expression increased significantly in both exercise groups compared to the control (p<0.01), with a more pronounced increase in the combined group relative to the aerobic group (p<0.01). Conclusion: The findings indicate that combined training has a greater impact than aerobic training in improving cardiac health markers. However, more extensive studies are needed for definitive conclusions. |
Type of Study: Research |
Subject:
Medical Sciences / Sports Medicine
Received: 2025/05/27 | Accepted: 2025/08/7 | Published: 2025/09/1
Received: 2025/05/27 | Accepted: 2025/08/7 | Published: 2025/09/1
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