Volume 12, Issue 1 (5-2025)
J Jiroft Univ Med Sci 2025, 12(1): 1819-1830 |
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Baziar F, Shabani R. Synergistic Evaluation of Aerobic Exercises and Saffron Extract on the amount of Amyloid Beta Accumulation and Cognitive Function in Induced Alzheimer's Rats. J Jiroft Univ Med Sci 2025; 12 (1) :1819-1830
URL: http://journal.jmu.ac.ir/article-1-821-en.html
URL: http://journal.jmu.ac.ir/article-1-821-en.html
1- PhD in Exercise Physiology, General Directorate of Sports and Youth of Gilan Province, Rasht, Iran , Fazelbazyar@yahoo.com
2- Associate Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
2- Associate Professor of Exercise Physiology, Department of Physical Education and Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran
Abstract: (28 Views)
Introduction: Alzheimer's disease is one of the serious challenges for the scientific and medical community. This progressive disorder severely weakens brain function and disrupts thinking and memory, and no definitive treatment has been found for it yet. Much research has been done to find ways to improve and compensate for the effects of this disease. Our aim in this article is to investigate the combined effect of aerobic exercises and consumption of saffron extract on spatial memory and the amount of beta-amyloid accumulation in the hippocampal tissue of animal models with Alzheimer's disease.
Materials and Methods: In this experimental study, 32 adult male rats were randomly divided into four Alzheimer's groups including control, aerobic exercise, aerobic exercise + extract, and extract. To create an Alzheimer's model, amyloid beta 42-1 was injected into the hippocampus. Rats in the extract and exercise groups received the extract at a rate of 100 mg per kilogram of body weight, once a day at 8 am, for 12 weeks via gavage. Aerobic exercise was performed for 12 weeks, including 3 sessions per week. To assess spatial memory, the radial maze test was used, and amyloid beta protein was measured by Elisa.One-way analysis of variance was used to analyze the data.
Results: The results showed that after 12 weeks of aerobic exercises with the consumption of saffron extract, spatial memory performance in the intervention groups increased significantly compared to the control group (p<0.05). Also, the amount of amyloid-beta accumulation in the groups that received aerobic exercise, aerobic exercise with extract, and only extract was significantly reduced compared to the control group (p≤0.05). Conclusion: It seems that aerobic exercises and the consumption of saffron extract help improving the performance of spatial memory and lead to the reduction of beta-amyloid accumulation in the hippocampal tissue of male rats with Alzheimer's disease. |
Type of Study: Research |
Subject:
Medical Sciences / Sports Medicine
Received: 2024/12/30 | Accepted: 2025/04/6 | Published: 2025/05/31
Received: 2024/12/30 | Accepted: 2025/04/6 | Published: 2025/05/31
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