Volume 11, Issue 4 (2-2025)
J Jiroft Univ Med Sci 2025, 11(4): 1735-1746 |
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Kordi khandae M, Sharafi deharham F, Valipour dehnou V, Roozbahani M. The Effect of the Eight Week of High-intensity Interval Training and Bee Pollen Consumption on Pain Tolerance and Type 1 Cannabinoid Receptors in Rats Exposed to Cadmium. J Jiroft Univ Med Sci 2025; 11 (4) :1735-1746
URL: http://journal.jmu.ac.ir/article-1-825-en.html
URL: http://journal.jmu.ac.ir/article-1-825-en.html
1- PhD Student Department of Exercise Physiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Assistant Professor, Department of Physical Education and Sports Sciences, Islamic Azad University, Khorramabad, Iran ,firuz.sharafidehrahm@iau.ac.ir
3- Associate Professor, Sports Sciences Department, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran
4- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
2- Assistant Professor, Department of Physical Education and Sports Sciences, Islamic Azad University, Khorramabad, Iran ,
3- Associate Professor, Sports Sciences Department, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran
4- Assistant Professor, Department of Motor Behavior, Borujerd Branch, Islamic Azad University, Borujerd, Iran
Abstract: (229 Views)
Introduction: Cadmium is a highly toxic environmental pollutant that has no physiological function in the human body and sometimes accumulates in the brain, causing neuronal damage and neurological disorders. In contrast, exercise and pollen supplementation are effective against neurological damage due to their antioxidant and anti-inflammatory effects. In this study, the impact of eight weeks of intense interval training and pollen consumption on pain threshold and type1cannabinoid receptors in rats exposed to cadmium was investigated.
Materials and Methods: In this experimental study, 25 male rats were randomly divided into five groups: healthy control, cadmium, pollen, high-intensity interval training, and pollen + high-intensity interval training. They performed high-intensity interval training three sessions per week for eight weeks. At the same time, pollen (200 mg dissolved in 4.2cc of normal saline) cadmium chloride (40 mg/kg/w/d dissolved in drinking water) were fed daily. Pain threshold was measured using a hot plate test and CB1r using the PCR method. Two-way analysis of variance and t-test were used for data analysis at a significance level of P<0.05.
Results: Pain threshold andCB1r in the pollen group were significantly higher than in the cadmium group (p<0.05). No significant difference was observed in the exercise group for pain threshold (p<0.05). CB1r was significant in the exercise group compared to the cadmium group (p>0.05). The interaction effect of exercise + pollen for pain threshold and CB1r was not significant (p<0.05). Conclusion: It is possible that exercise and pollen could be effective in improving the function of type 1 cannabinoid receptors, and pollen consumption could be effective in increasing pain tolerance in mice exposed to cadmium. |
Type of Study: Research |
Subject:
Medical Sciences / Physiology
Received: 2024/12/13 | Accepted: 2026/02/10 | Published: 2025/02/28
Received: 2024/12/13 | Accepted: 2026/02/10 | Published: 2025/02/28
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