Volume 11, Issue 2 (8-2024)
J Jiroft Univ Med Sci 2024, 11(2): 1544-1553 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Arabmomeni A, Salar Abdellah Hamid D. Investigating the Effects of Capsaicin Consumption on Weight Loss, Fat Percentage, and Ghrelin Hormone Levels of Adolescents with Overweight: A Semi Experimental Research. J Jiroft Univ Med Sci 2024; 11 (2) :1544-1553
URL: http://journal.jmu.ac.ir/article-1-778-en.html
URL: http://journal.jmu.ac.ir/article-1-778-en.html
1- Assistant Professor in Exercise Physiology, Department of Sports Sciences, School of Human Sciences, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr/Isfahan, Iran
2- M.As Candidate in Exercise Physiology, Department of Sport physiology, School of Physical Education & Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2- M.As Candidate in Exercise Physiology, Department of Sport physiology, School of Physical Education & Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
Abstract: (872 Views)
Introduction: Today, life style interventions, including exercise, diet, and behavioral therapy are recommended for weight loss; however, these interventions have not been very successful. Therefore, the objective of this study was to investigate the effects of capsaicin consumption on weight loss, fat percentage, and ghrelin hormone in male adolescents with overweight.
Materials and Methods: In this quasi-experimental study, with a pre-test-post-test design, 30 overweight teenagers with BMI=26.52 kg/m2 were selected purposefully and were randomly divided into 2 equals groups (Supplement and Placebo). The supplement group consumed 50 mg of capsaicin daily with their usual breakfast for 16 weeks. Blood sampling and measuring fat percentage were done in the pre-test, in the 8th week, and 16th weeks. In addition, in order to analyze the data, covariance test was used using SPSS26 software (p<0.05).
Results: The results showed that in the 8th week of the intervention, the average weight, BMI and fat percentage decreased, but this decrease was significant only in the level of weight (p<0.05). However, in the 16th week, all these variables became significant. In addition, the consumption of capsaicin supplements increased the levels of the ghrelin hormone, but this increase was significant only in the 16th week (p<0.05). Conclusion: These findings indicate the beneficial effects of capsaicin supplementation on body composition and ghrelin hormone in overweight adolescents. Therefore, the use of this herbal supplement along with regular meals is recommended as an intervention method to reduce weight and obesity. |
Type of Study: Research |
Subject:
Health Sciences / Nutrition
Received: 2024/05/12 | Accepted: 2024/07/19 | Published: 2024/08/31
Received: 2024/05/12 | Accepted: 2024/07/19 | Published: 2024/08/31
References
1. NCD risk factor collaboration (NCD-RisC). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. Lancet. 2020 7;396(10261):1511-24. [DOI:10.1530/ey.18.13.15]
2. Popovic S, Starc G, Soric M, Jarani J. Editorial: Children's development during social transition. Front Public Health. 2021;9:794444. [DOI:10.3389/fpubh.2021.794444]
3. Lin X, Li H. Obesity: epidemiology, pathophysiology, and therapeutics. front endocrinol (Lausanne). 2021;12:706978. [DOI:10.3389/fendo.2021.706978]
4. Di Cesare M, Sorić M, Bovet P, Miranda JJ, Bhutta Z, Stevens GA, et al. The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action. BMC Medicine. 2019;17(1):212. [DOI:10.1186/s12916-019-1449-8]
5. Salam RA, Padhani ZA, Das JK, Shaikh AY, Hoodbhoy Z, Jeelani SM, et al. Effects of lifestyle modification interventions to prevent and manage child and adolescent obesity: A Systematic review and meta-analysis. Nutrients. 2020;12(8):2208. [DOI:10.3390/nu12082208]
6. Knop C, Singer V, Uysal Y, Schaefer A, Wolters B, Reinehr T. Extremely obese children respond better than extremely obese adolescents to lifestyle interventions. Pediatric Obesity. 2015 (1):7-14. [DOI:10.1111/j.2047-6310.2013.00212.x]
7. Yim MH, Lee B. Factors affecting the use of herbal medicines for weight loss in overweight and obese adolescents. Frontiers in Pediatrics. 2023;11:1166786. [DOI:10.3389/fped.2023.1166786]
8. Kumar M, Kaushik D, Kaur J, Proestos C, Oz F, Oz E, et al. A critical review on obesity: Herbal approach, bioactive compounds, and their mechanism. Applied Sciences. 2022; 12(16):8342. [DOI:10.3390/app12168342]
9. Broom DR, Stensel DJ, Bishop NC, Burns SF, Miyashita M. Exercise-induced suppression of acylated ghrelin in humans. Journal of Applied Physiology (1985). 2007;102(6):2165-71. [DOI:10.1152/japplphysiol.00759.2006]
10. Duncker DJ, Bache RJ. Regulation of coronary blood flow during exercise. Physiological Reviews. 2008;88(3):1009-86. [DOI:10.1152/physrev.00045.2006]
11. Gomes MR, Tirapegui J. Relação de alguns suplementos nutricionais e o desempenho físico [Relation of some nutritional supplements and physical performance]. Archivos Latinoamericanos de Nutrición. 2000; 50(4):317-29.
12. Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. The British Journal of Nutrition. 1998; 80(6):503-10. [DOI:10.1017/S0007114598001597]
13. Rogers J, Urbina SL, Taylor LW, Wilborn CD, Purpura M, Jäger R, Juturu V. Capsaicinoids supplementation decreases percent body fat and fat mass: adjustment using covariates in a post hoc analysis. BMC Obesity. 2018;5:22. [DOI:10.1186/s40608-018-0197-1]
14. Westerterp-Plantenga MS, Smeets A, Lejeune MP. Sensory and gastrointestinal satiety effects of capsaicin on food intake. International Journal of Obesity (Lond). 2005;29(6):682-8. [DOI:10.1038/sj.ijo.0802862]
15. Bort A, Sánchez BG, Mateos-Gómez PA, Díaz-Laviada I, Rodríguez-Henche N. Capsaicin targets lipogenesis in HepG2 cells through AMPK activation, AKT inhibition and PPARs regulation. International Journal of Molecular Sciences. 2019;20(7):1660. [DOI:10.3390/ijms20071660]
16. Mostafavian M, Abdi A, Mehrabani J, Barari A. Synergistic Effects of aerobic training and capsaicin on FNDC5 gene expression and Irisin protein level of visceral adipose tissue in Rat Fed a High-Fat Diet. Metabolism and Exercise 2020; 10(2). (in Persian).
17. Rossi PAQ, Lira FS, Bezerra VR, Clark NW, Fukuda DH, Panissa VLG. Acute response to capsiate supplementation at rest and during exercise on energy intake, appetite, metabolism, and autonomic function: A randomized trial. Journal of the American Nutrition Association. 2022; 41(6):541-550. [DOI:10.1080/07315724.2021.1938294]
18. Faul F, Erdfelder E, Lang A-G, Buchner A. G* Power 3: A Flexible statistical power analysis program for the social. Behavioral, And Biomedical Sciences. Behavior Research Methods 2007; 39(2): 175-191. [DOI:10.3758/BF03193146]
19. Moghaddam MB, Aghdam FB, Jafarabadi MA, Allahverdipour H, Nikookheslat SD, Safarpour S. The Iranian version of international physical activity questionnaire (IPAQ) in Iran: content and construct validity, factor structure, internal consistency and stability. World Applied Sciences Journal 2012; 18 (8): 1073-1080.
20. Tully MA, Cupples ME. UNISTEP (university students exercise and physical activity) study: a pilot study of the effects of accumulating 10,000 steps on health and fitness among university students. Journal of Physical Activity & Health. 2011; 8(5): 663-667. [DOI:10.1123/jpah.8.5.663]
21. Koozehchian MS, Nazem F, Kreider RB, Roberts WJ, Best TM, Rong Y, et al .The roleof exercise training on lipoprotein profiles in adolescent males. Lipids in Health Anddisease 2014;13(1):95. [DOI:10.1186/1476-511X-13-95]
22. Long Y, Ye H, Yang J, Tao X, Xie H, Zhang J, Zhong Y, Wang M. Effects of a vegetarian diet combined with aerobic exercise on glycemic control, insulin resistance, and body composition: a systematic review and meta-analysis. Eating and Weighting Disorders. 2023;28(1):9. [DOI:10.1007/s40519-023-01536-5]
23. de Lourdes Medina-Contreras JM, Mailloux-Salinas P, Colado-Velazquez JI, Gómez-Viquez NLGV, Velázquez-Espejel R, Del Carmen Susunaga-Notario A, et al. Topical capsaicin cream with moderate exercise protects against hepatic steatosis, dyslipidemia and increased blood pressure in hypoestrogenic obese rats. Journal of the Science of Food and Agriculture. 2020;100(7):3212-19. [DOI:10.1002/jsfa.10357]
24. Medina-Contreras JML, Colado-Velázquez J 3rd, Gómez-Viquez NL, Mailloux-Salinas P, Pérez-Torres I, et al. Effects of topical capsaicin combined with moderate exercise on insulin resistance, body weight and oxidative stress in hypoestrogenic obese rats. International Journal of Obesity (Lond). 2017;41(5):750-8. [DOI:10.1038/ijo.2017.33]
25. Urbina SL, Roberts MD, Kephart WC, Villa KB, Santos EN, Olivencia AM, et al. Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals. Appetite. 2017;113:264-273. [DOI:10.1016/j.appet.2017.02.025]
26. Lee GR, Shin MK, Yoon DJ, Kim AR, Yu R, Park NH, et al. Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (Silver Spring). 2013;21(1):115-22. [DOI:10.1002/oby.20246]
27. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. The American Journal of Clinical Nutrition. 2009;89(1):45-50. [DOI:10.3945/ajcn.2008.26561]
28. Osuna-Prieto FJ, Acosta FM, Perez de Arrilucea Le Floc'h UA, Riquelme-Gallego B, Merchan-Ramirez E, Xu H, De La Cruz-Márquez JC, et al. Dihydrocapsiate does not increase energy expenditure nor fat oxidation during aerobic exercise in men with overweight/obesity: a randomized, triple-blinded, placebo-controlled, crossover trial. Journal of the International Society of Sports Nutrition. 2022 Jul 19;19(1):417-36. [DOI:10.1080/15502783.2022.2099757]
29. Inoue N, Matsunaga Y, Satoh H, Takahashi M. Enhanced energy expenditure and fat oxidation in humans with high BMI scores by the ingestion of novel and non-pungent capsaicin analogues (capsinoids). Bioscience, Biotechnology Biochemistry. 2007;71(2):380-9. [DOI:10.1271/bbb.60341]
30. Joo J.I, Kim D.H, Choi J.W, Yun J.W. Proteomic analysis for ant obesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet. Journal of Proteome Research, 2010; (9): 2977e2987. [DOI:10.1021/pr901175w]
31. Smeets A.J., Westerterp-Plantenga M.S. The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. European Journal of Nutrition. 2009;48:229-234. [DOI:10.1007/s00394-009-0006-1]
32. Janssens P.L., Hursel R., Westerterp-Plantenga M.S. Capsaicin increases sensation of fullness in energy balance, and decreases desire to eat after dinner in negative energy balance. Appetite. 2014; 77:44-9. [DOI:10.1016/j.appet.2014.02.018]
33. Akbarpour M. The effect of concurrent training on ghrelin, growth and insulin hormones in obese men. Journal of Physiology of Sports and Physical Activity. 2011; 4(2): 4(1):28-20. (in Persian).
34. Algul S, Ilcin S, Ozcelik O. Effects of excercise on ghrelin. Progress in Nutrition [Internet]. 2021; 23(3):e2021114.1-11.
35. Murawska-Cialowicz E, Wierzbicka-Damska I, Bakonska-Pacon E, Kalwa M, Dziegiel P. Impact of nine month health training and a single exercise on changes in ghrelin, leptin and free fatty acids levels in women's blood. Central European Journal of Sport Sciences and Medicine. 2015;3(1). https://wnus.edu.pl/cejssm/en/
36. Zheng J, Zheng S, Feng Q, Zhang Q, Xiao X. Dietary capsaicin and its anti-obesity potency: from mechanism to clinical implications. Bioscience Reports. 2017;37(3):BSR20170286. [DOI:10.1042/BSR20170286]
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
