Volume 11, Issue 1 (5-2024)                   J Jiroft Univ Med Sci 2024, 11(1): 1489-1496 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kabiri M, Askari B, Habibian M. The Effect of a Course of High-Intensity Interval Running Training with Vitamin D Intake on TSH and MCP-1 Levels in Overweight Women with Vitamin D Deficiency. J Jiroft Univ Med Sci 2024; 11 (1) :1489-1496
URL: http://journal.jmu.ac.ir/article-1-764-en.html
1- MA of Physical Education, Department of Physical Education and Sport Sciences, Qaemshahr Branch,Islamic Azad University, Qaemshahr, Iran
2- Assistant Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran , babisan.askari@gmail.com
3- Associate Professor, Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran
Abstract:   (416 Views)
Introduction: High body mass index and vitamin deficiency are considered to be the main factors of thyroid and fat tissue dysfunction. The aim of the present study was to investigate the effect of a period of high intensity running training with vitamin D consumption on TSH and MCP-1 levels in overweight women with vitamin D deficiency.
Materials and Methods: This semi-experimental study was conducted on 26 overweight young women with vitamin D deficiency in Babol city, in 1400. After the accessible and purposeful selection, the subjects were randomly divided into two intervention and control groups. The main training consisted of 8 weeks of high intensity running with an intensity of 80-90% of the maximum heart rate and one minute of active rest with an intensity of 50% of the maximum heart rate during 8 weeks, and vitamin D was taken at a dose of 50,000 units weekly. Serum levels of TSH and MCP-1 were determined before and after 8 weeks. Independent t and paired t tests were used to analyze the data at a significance level of P≤0.05.
Results: Data analysis showed that the serum levels of TSH and MCP-1 decreased significantly in the intervention group after 8 weeks. In addition, a significant difference in the mean of TSH and MCP-1 between the intervention and control groups was observed (p<0.001).
Conclusion: Based on the results, the simultaneity of intense intermittent running and vitamin D intake can help increase the health of overweight people with vitamin D intake, by improving thyroid function and reducing the inflammatory index of MCP-1.
Full-Text [PDF 713 kb]   (115 Downloads)    
Type of Study: Research | Subject: Medical Sciences / Physiology
Received: 2024/02/18 | Accepted: 2024/05/21 | Published: 2024/06/30

References
1. Byeon H, Moon Y, Lee S, Son GI, Lee E. Effect of the marine exercise retreat program on thyroid-related hormones in middle-aged euthyroid women. International Journal of Environmental Research and Public Health. 2023;20(2):1542. [DOI:10.3390/ijerph20021542]
2. Ağbaht K, Pişkinpaşa SV. Serum TSH, 25(OH) D and phosphorus levels predict weight loss in individuals with diabetes/prediabetes and morbid obesity: a single-center retrospective cohort analysis. BMC Endocrine Disorders. 2022,18;22(1):282. [DOI:10.1186/s12902-022-01202-4]
3. Agbaht K, Mercan Y, Kutlu S, Alpdemir MF, Sezgin T. Obesity with and without metabolic syndrome: do vitamin D and thyroid autoimmunity have a role? Diabetes Research and Clinical Practice. 2014;106:27-34. [DOI:10.1016/j.diabres.2014.08.001]
4. Ceglia L, Nelson J, Ware J, Alysandratos KD, Bray GA, Garganta C, et al. Diabetes prevention program research G. Association between body weight and composition and plasma 25-hydroxyvitamin D level in the diabetes prevention program. European Journal of Nutrition. 2017;56:161-70. [DOI:10.1007/s00394-015-1066-z]
5. Pasquali R, Casanueva F, Haluzik M, van Hulsteijn L, Ledoux S, Monteiro MP, et al. European society of endocrinology clinical practice guideline: Endocrine work-up in obesity. European Journal of Endocrinology. 2020;182(1): 1-32. [DOI:10.1530/EJE-19-0893]
6. Babić Leko M, Jureško I, Rozić I, Pleić N, Gunjača I, Zemunik T. Vitamin D and the thyroid: a critical review of the current evidence. International Journal of Molecular Sciences. 2023; 24(4):3586. [DOI:10.3390/ijms24043586]
7. Walczak K, Sieminska L. Obesity and thyroid axis. International Journal of Environmental Research and Public Health. 2021. 7;18(18):9434. [DOI:10.3390/ijerph18189434]
8. Gupta G, Sharma, Pn Kumar P, Itagappa M. Study on subclinical hypothyroidism and its association with various inflammatory markers. Journal of Clinical and Diagnostic Research. 2015;9(11):BC04-BC06. [DOI:10.7860/JCDR/2015/14640.6806]
9. Yang C, He Z, Zhang Q, Lu M, Zhao J, Chen W, et al. TSH activates macrophage inflammation by G13- and G15-dependent pathways. Endocrinology 2021; 162(8):bqab077. [DOI:10.1210/endocr/bqab077]
10. Zhang YJ, Zhao W, Zhu MY, Tang SS, Zhang H. Thyroid-stimulating hormone induces the secretion of tumor necrosis factor-_ from 3T3-L1 adipocytes via a protein kinase A-dependent pathway. Experimental and Clinical Endocrinology and Diabetes 2013; 121:488-93. [DOI:10.1055/s-0033-1347266]
11. Gulgun M. The level of monocyte chemoattractant protein-1 may be affected by several factors. Medical Principles and Practice. 2018; 27(4):400. [DOI:10.1159/000490189]
12. Yoshimura T. The production of monocyte chemoattractant protein-1 (MCP-1)/CCL2 in tumor microenvironments. Cytokine. 2017;98:71-8. [DOI:10.1016/j.cyto.2017.02.001]
13. Raoof IB, Mohsin RA, Okhti ZA. The Prevalence Role of monocyte chemoattractant protein-1 in Hashimoto's thyroiditis via various stimuli mechanisms. Journal of Pharmacy and Bioallied Sciences. 2021;13(2):244-47. [DOI:10.4103/jpbs.JPBS_746_20]
14. Bansal A, Kaushik A, Singh C M, Sharma V, Singh H. The effect of regular physical exercise on the thyroid function of treated hypothyroid patients: An interventional study at a tertiary care center in Bastar region of India . Archives of Medicine and Health Sciences. 2015;3:244-6. [DOI:10.4103/2321-4848.171913]
15. Mehravar MR. The effect of eight-week Pilates exercise on the thyroid function in sedentary women. Journal of Physical Activity and Hormones 2018;50(2): 02942.
16. Onsori M, Galedari M. Effects of 12 weeks aerobic exercise on plasma level of TSH and thyroid hormones in sedentary women. European Journal of Sports and Exercise Science 2015; 4 (1):45-9.
17. Cassidy S, Vaidya V, Houghton D et al. Unsupervised high-intensity interval training improves glycaemic control but not cardiovascular autonomic function in type 2 diabetes patients: a randomised controlled trial. Diabetes & Vascular Disease Research.2019; 16(1):69-76. [DOI:10.1177/1479164118816223]
18. Russomando L, Bono V, Mancini A, Terracciano A, Cozzolino F, Imperlini E, et al. The effects of short-term high-intensity interval training and moderate intensity continuous training on body fat percentage, abdominal circumference, BMI and VO2max in overweight subjects. Journal of Functional Morphology and Kinesiology. 2020;5(2):41. [DOI:10.3390/jfmk5020041]
19. Galușca D, Popoviciu MS, Babeș EE, Vidican M, Zaha AA, Babeș VV, et al. Vitamin D implications and effect of supplementation in endocrine disorders: Autoimmune thyroid disorders (Hashimoto's disease and Grave's disease), diabetes mellitus and obesity. Medicina (Kaunas). 2022;58(2):194. [DOI:10.3390/medicina58020194]
20. Journy NMY, Bernier MO, Doody MM, Alexander BH, Linet MS, Kitahara CM. Hyperthyroidism, hypothyroidism, and cause-specific mortality in a large cohort of women. Thyroid. 2017;27(8):1001-1010. [DOI:10.1089/thy.2017.0063]
21. Pourfarzi F, Sadjadi A, Poustchi H, Amani F. Prevalence of overweight and obesity in Iranian population: A population-based study in northwestern of Iran. International Journal of Public Health Research. 2021;11(1):2475. [DOI:10.4081/jphr.2021.2475]
22. Ebrahemi Rokni F, Habibian M, Farajtabar Behrestaq S. The effectiveness of pilates training and vitamin D intake on the hs-CRP and TSH in overweight men. Journal of Inflammatory Diseases. 2021; 25(1):31-38. (Persian) [DOI:10.32598/JQUMS.25.1.8]
23. Poon ETC, Siu PMF, Wongpipit W, Gibala M, Wonga SHS. Alternating high-intensity interval training and continuous training is efficacious in improving cardiometabolic health in obese middle-aged men. Journal of Exercise Science & Fitness 2022;20 (21): 40-47. [DOI:10.1016/j.jesf.2021.11.003]
24. Abassi W, Ouerghi N, Ghouili H, Haouami S, Bouassida A. Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls. Hormone Molecular Biology and Clinical Investigation 2020;41(4): 20200031. [DOI:10.1515/hmbci-2020-0031]
25. Akbulut, T, Cınar, V. ve Erdogan, R. The effect of high intensity interval training applied with vitamin E reinforcement on thyroid hormone metabolism. Revista Romaneasca Pentru Educatie Multidimensionala;11 (4):1-7.
26. Klasson CL, Sadhir S, Pontzer H. Daily physical activity is negatively associated with thyroid hormone levels, inflammation, and immune system markers among men and women in the NHANES dataset. PLoS One. 2022;17(7):e0270221. [DOI:10.1371/journal.pone.0270221]
27. Das G, Taylor PN, Javaid H, Tennant BP, Geen J, Aldridge A, et al. Seasonal variation of vitamin D and serum thyrotrpin levels and its relationship in a euthyroid cacasian population. Endocrine Practice.;2018;24(1):53-59. [DOI:10.4158/EP-2017-0058]
28. Zhang Q, Wang Z, Sun M, Cao M, Zhu Z, Fu Q, et al. Association of high vitamin d status with low circulating thyroid-stimulating hormone independent of thyroid hormone levels in middle-aged and elderly males. International Journal of Endocrinology. 2014;2014(1):631819. [DOI:10.1155/2014/631819]
29. Bruun J M, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. American Journal of Physiology: Endocrinology and Metabolism. 2006;290(5): E961-7. [DOI:10.1152/ajpendo.00506.2005]
30. Habibian M, Farzanegi P, Sadat Tabar Bisheh S M. The combined effects of pilates training and Apium Graveolens seed supplement on the levels of inflammatory monocyte chemoattractant protein -1 and C-reactive protein in sedentary women. Journal of Arak University of Medical Sciences. 2015; 18 (9) :39-48.(Persian)
31. Sadeghi Shirsavar H, Habibian M, Farajtabar Behrestaq S. Effect of One course of pilates training with vitamin D supplement on monocyte chemoattractant protein-1 level and superoxide dismutase activity in overweight men: A Clinical Trial Study. Journal of Gorgan University of Medical Sceinces 2022; 24 (1) :10-18. (Persian)
32. Zhang, YJ, Zhao W, Zhu, MY, Tang, SS, Zhang, H. Thyroid-stimulating hormone induces the secretion of tumor necrosis factor-_ from 3T3-L1 adipocytes via a protein kinase A-dependent pathway. Experimental and Clinical Endocrinology and Diabetes 2013; 121:488-93. [DOI:10.1055/s-0033-1347266]
33. Yang C, He Z, Zhang Q, Lu M, Zhao J, Chen W, et al. TSH activates macrophage inflammation by G13- and G15-dependent pathways. Endocrinology 2021; 162(8):1-10. [DOI:10.1210/endocr/bqab077]
34. Park CY, Kim TY, Yoo JS, Seo Y, Pae M, Han SN. Effects of 1,25-dihydroxyvitamin D3 on the inflammatory responses of stromal vascular cells and adipocytes from lean and obese mice. Nutrients. 2020;12(2):364. [DOI:10.3390/nu12020364]
35. Kokkotou E, Marafelia P, Mantzos EI, Tritos NA. Serum monocyte chemoattractant protein-1 is increased in chronic autoimmune thyroiditis. Metabolism. 2002;51(11):1489-93. [DOI:10.1053/meta.2002.34717]
36. Troseid M, Lappegard KT, Claudi T, Damas JK, Morkrid L, Brendberg R, Mollnes TE. Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome. European Heart Journal. 2004;25(4):349-55. [DOI:10.1016/j.ehj.2003.12.006]

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Jiroft University of Medical Sciences

Designed & Developed by : Yektaweb