fa اثر یک دوره فعالیت ورزشی مقاومتی با دو شدت و ریکاوری متفاوت بر فاکتورهای تومورنکروز آلفا، پروتئین شوک حرارتی 70 کیلودالتونی، پروتئین واکنشی سی و فاکتور نوروتروفیک مشتق از مغز سرم خونِ زنان بدنساز علوم پزشکی / فيزيولوژي Medical Sciences / Physiology پژوهشي Research <div> <table align="left" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0cm 12px; text-align: justify;" valign="top"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">مقدمه و هدف:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">تمرینات مقاومتی با بار زیاد موجب تغییرات فیزیولوژیکی در سیستم ایمنی می &shy;شود که بر سلامت و کارایی ورزشکار تاثیر دارد. این مطالعه، اثر یک وهله فعالیت مقاومتی با دو شدت و ریکاوری متفاوت را بر فاکتور های<a name="_Hlk156752114"> </a></span></span>TNF-&alpha;<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>hs-CRP <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">و </span></span>HSP-70 <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">و </span></span>BDNF<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> سرم خون زنان بدنساز را </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">بررسی کرد.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">روش کار:</span></span></b><a name="_Hlk156752602"> </a><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">در این مطالعه نیمه تجربی، 12 زن ورزشکار بدنساز سالم با بازه سنی 25 تا 35 سال، داوطلب شدند، پس از پر کردن فرم رضایت نامه، برنامه&shy; های تمرینی با شدت&shy; های 75% و 85% یک تکرار بیشینه (</span></span>1RM<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) را با دو زمان ریکاوری یک و دو دقیقه اجرا کردند. 36 ساعت بعد از هر جلسه تمرین و پس از 10 ساعت ناشتایی، نمونه &shy;گیری خونی انجام شد. نمونه&shy; های خونی با 4000 دور در دقیقه سانتریفیوژ و در دمای </span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" math="" style="font-family:">℃</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">20- نگهداری شدند. در پایان همه مقادیر </span></span>TNF-<b>&alpha;</b>، <a name="_Hlk156752636">hs-CRP</a> ،HSP-70 و<b> </b>BDNF<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> هر چهار مرحله، هم زمان روی سرم خون بررسی شد. جهت تجزیه و تحلیل داده&shy; ها نیز از نرم افزار </span></span>SPSS<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> نسخه 27 در سطح معناداری 0/05</span></span>&le;p&nbsp;<span style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> استفاده شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">یافته&shy; ها:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">براساس نتایج، تمرین مقاومتی با شدت بالا </span></span>( 1RM <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">85%) و ریکاوری یک دقیقه در مقایسه با تمرینات مقاومتی با شدت کمتر کاهش معناداری در سطح </span></span>TNF-&alpha;<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (</span></span>p<<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">0/001) و میزان</span></span> hs-CRP<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (</span></span>p<<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">0/025) و </span></span>HSP-70<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (</span></span>p<<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">0/001) و همچنین افزایش معناداری در سطح <a name="_Hlk162290119">سرمی</a></span></span> BDNF <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">(</span></span>p<<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">0/001) مشاهده شد.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">نتیجه‌گیری:</span></span></b> &nbsp;HLRT<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> اثر منفی بر سیستم ایمنی نداشته و احتمالا موجب کاهش فاکتورهای </span></span>TNF-&alpha;<a href="#_ftn1" name="_ftnref1" title="">^{^{<span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[1]</span></span></span>}}</a><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>hs-CRP<a href="#_ftn2" name="_ftnref2" title="">^{^{<span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[2]</span></span></span>}}</a><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">، </span></span>HSP-70<a href="#_ftn3" name="_ftnref3" title="">^{^{<span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[3]</span></span></span>}}</a><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و افزایش فاکتو</span></span>BDNF<a href="#_ftn4" name="_ftnref4" title="">^{^{<span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[4]</span></span></span>}}</a>&nbsp; <span style="font-size:12.0pt"><span b="" mitra="" style="font-family:">&nbsp;در زنان بدنساز می</span></span>&shy;<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">گردد.</span></span></span></span></span></span></span></span></td> </tr> </tbody> </table> </div> <div><div style="text-align: justify;"></div> <hr align="left" size="1" width="33%" > <div id="ftn1" style="text-align: justify;"><span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><a href="#_ftnref1" name="_ftn1" title=""><span class="MsoFootnoteReference" style="vertical-align:super"><span class="MsoFootnoteReference" style="vertical-align:super"><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[1]</span></span></span></span></span></a> Tumor Necrosis Factor-alpha</span></span></div> <div id="ftn2" style="text-align: justify;"><span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><a href="#_ftnref2" name="_ftn2" title=""><span class="MsoFootnoteReference" style="vertical-align:super"><span class="MsoFootnoteReference" style="vertical-align:super"><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[2]</span></span></span></span></span></a> C-Reactive Protein&nbsp;</span></span></div> <div id="ftn3" style="text-align: justify;"><span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><a href="#_ftnref3" name="_ftn3" title=""><span class="MsoFootnoteReference" style="vertical-align:super"><span class="MsoFootnoteReference" style="vertical-align:super"><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[3]</span></span></span></span></span></a> Heat-Shock Proteins</span></span></div> <div id="ftn4" style="text-align: justify;"><span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><a href="#_ftnref4" name="_ftn4" title=""><span class="MsoFootnoteReference" style="vertical-align:super"><span class="MsoFootnoteReference" style="vertical-align:super"><span style="font-size:10.0pt"><span style="line-height:110%"><span new="" roman="" style="font-family:" times="">[4]</span></span></span></span></span></a> Brain-Derived Neurotrophic Factor</span></span></div> </div> <div style="text-align: justify;"></div> <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td align="left" style="padding-top:0cm; padding-right:12px; padding-bottom:0cm; padding-left:12px" valign="top"> <pre style="text-align: justify;"> <span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span courier="" new="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction</span></b><b><span new="" roman="" style="font-family:" times="">:</span></b> <span new="" roman="" style="font-family:" times="">Resistance training with high loads of HLRT causes physiological changes in the immune system, affecting the athlete&#39;s health and performance. This study investigated the effect of a period of resistance activity with two different intensities and recovery on TNF -&alpha;, hs-CRP, HSP-70, and BDNF in the blood serum of female bodybuilders.</span><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></pre> <pre style="margin-top: 16px; text-align: justify;"> <span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span courier="" new="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials </span></b><b><span new="" roman="" style="font-family:" times="">and Methods</span></b>: <span new="" roman="" style="font-family:" times="">In this semi-experimental study, 12 healthy female bodybuilders (age 30&plusmn;5) volunteers, after filling out the consent form, performed exercise programs with 70% and 85% 1RM intensities and two recovery times of one and two minutes. 36 hours after each exercise, blood sampling was done after fasting for 10 hours. Plasma was separated from blood cells by centrifuging at 4000g for 10 min, clear plasma supernatant was aliquot, and stored at &minus;20&deg;C until required for use. In the end, all levels of TNF-&alpha;, hs-CRP, HSP-70, and BDNF were checked simultaneously. SPSS version 27 software was used to analyze the data at a significance level of p&le;0.05.</span><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></pre> <div style="text-align: justify;"><span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b>Results:</b> Based on the results, high-intensity resistance training (HLRT) compared to moderate-intensity resistance training (MLRT), with an increase in training intensity up to 85% 1RM and a one-minute recovery, significantly reduced TNF-&alpha; levels (p<0.001), and hs-CRP (p<0.025) and HSP-70 (p<0.0001),&nbsp; also resulted in a significant increase in BDNF serum level (p<0.0001).</span></span></span></span></span><br> <span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> Increasing the intensity of HLRT resistance training has no negative effect on the immune system, and this is probably due to the reduction of the pro-inflammatory factors TNF-&alpha;, hs-CRP, and HSP-70 and the increase of the BDNF factor in female bodybuilders.</span></span></span></span></span></div> </td> </tr> </tbody> </table> </div> <div style="text-align: justify;"></div> پروتئین واکنشی C, پروتئین های شوک حرارتی؛ تمرینات مقاومتی ؛ فاکتور نوروتروفیک مشتق از مغز؛ فاکتور نکروز تومور-آلفا. Brain-Derived Neurotrophic Factor, C-Reactive Protein, Heat-Shock Proteins, Tumor Necrosis Factor-alpha, Resistance training 1667 1678 http://journal.jmu.ac.ir/browse.php?a_code=A-10-927-1&slc_lang=fa&sid=1 Azar Momtaz آذر ممتاز azar.momtaz@gmail.com 10031947532846008678 10031947532846008678 No PhD Candidate in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran دانشجوی دکترای فیزیولوژی ورزشی ،گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران Ramin Shabani رامین شعبانی dr.ramin.shabani@gmail.com 10031947532846008679 10031947532846008679 Yes Professor in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran استاد، گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران Alireza Elmieh علیرضا علمیه 10031947532846008680 10031947532846008680 No Associate Professor in Exercise Physiology, Department of Physical Education and Sports Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran دانشیار، گروه تربیت بدنی و علوم ورزشی، واحد رشت، دانشگاه آزاد اسلامی، رشت، ایران