fa اثر تمرین هوازی با شدت متوسط بر سطوح سرمی اینترلوکین-6، اینترلوکین-10 و پروتئین واکنش گر C در بیماران بهبود یافته از کووید-19 علوم پزشکی / پزشکي ورزشي Medical Sciences / Sports Medicine پژوهشي Research <div> <table align="left" hspace="0" vspace="0"> <tbody> <tr> <td style="padding: 0cm 12px; text-align: justify;" valign="top"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">مقدمه و هدف:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">فعالیت ورزشی از جمله راهکارهای غیر تهاجمی جهت بازتوانی و پیشگیری از عوارض و عواقب بیماری</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">های مرتبط با کووید-19 می</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">باشد. هدف از این مطالعه بررسی اثر تمرین هوازی با شدت متوسط بر سطوح سرمی اینترلوکین-6، اینترلوکین-10 و پروتئین واکنش</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">گر </span></span>C<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در بیماران بهبود یافته از کووید-19 بود.</span></span></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">روش کار:</span></span></b> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:">این </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">مطالعه از نوع کارآزمایی بالینی کاربردی و با طرح پیش</span></span><span lang="AR-SA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">آزمون و پس &shy;آزمون بود.</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">بدین منظور 24 مرد بهبود یافته از کووید-19 به صورت داوطلبانه انتخاب و به شکل تصادفی ساده در دو گروه تجربی (12 نفر) و کنترل (12 نفر) قرار گرفتند. گروه تجربی برنامه تمرین هوازی شامل هشت هفته، هر هفته سه جلسه و هر جلسه 40 تا 55 دقیقه با شدتی معادل 60 تا 80% حداکثر ضربان قلب را اجرا کردند. سطوح سرمی </span></span>IL-6<b><span b="" mitra="" style="font-family:">، </span></b>IL-10<b> </b><span b="" mitra="" style="font-family:">و </span>CRP<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> (قبل و 48 ساعت بعد از پروتکل) اندازه</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">گیری شد. داده</span></span><span lang="FA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">ها با استفاده از آزمون آماری کوواریانس در سطح (0/05</span></span><b><span b="" mitra="" style="font-family:">></span></b>p<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) آنالیز شدند.</span></span><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></b></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">یافته&shy; ها:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">نتایج نشان داد که تمرین هوازی منجر به تغییر معنادار سطوح سرمی </span></span>IL-6<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>IL-10<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در گروه تجربی نسبت به گروه کنترل نشد (0/05</span></span><span b="" mitra="" style="font-family:"><</span>p<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">) اما باعث کاهش معنادار سطوح سرمی </span></span>CRP<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> در گروه تجربی گردید (0/05</span></span><span b="" mitra="" style="font-family:">></span>p<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). بررسی تغییرات درون گروهی مقدار </span></span>IL-10<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> و </span></span>CRP<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> نشان داد که بین میانگین قبل و بعد در گروه تجربی تغییر معناداری وجود دارد (0/05</span></span><span b="" mitra="" style="font-family:">></span>p<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">). در حالی که بین مقادیر قبل و بعد در </span></span>IL-6<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> تفاوت معناداری مشاهده نشد </span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">(0/05</span></span><span b="" mitra="" style="font-family:"><</span>p<span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">)</span></span><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">.</span></span><b><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></b></span></span></span></span></span></span><br> <span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span lang="FA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">نتیجه‌گیری:</span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">بر پایه نتایج این مطالعه اجرای تمرینات هوازی می</span></span><span cambria="" dir="LTR" style="font-family:">&shy;</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">تواند از طریق بازیابی توان فیزیکی در بیماران بهبود یافته از کووید-19، موجب تنظیم و تعادل سایتوکاین</span></span><span lang="AR-SA" style="font-size:12.0pt"><span cambria="" style="font-family:">&shy;</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:">های ضد التهابی و التهابی و تعدیل در مقدار </span></span>CRP<span lang="AR-SA" style="font-size:12.0pt"><span b="" mitra="" style="font-family:"> گردد.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Mitra""></span></span></span></span></span></span></span></span></td> </tr> </tbody> </table> </div> <div style="text-align: justify;"></div> <div> <table align="center" hspace="0" vspace="0"> <tbody> <tr> <td align="left" style="padding-top:0cm; padding-right:12px; padding-bottom:0cm; padding-left:12px" valign="top"> <div style="text-align: justify;"><span style="font-size:10pt"><span style="text-justify:inter-ideograph"><span style="line-height:110%"><span new="" roman="" style="font-family:" times=""><b>Introduction:</b> Sports activity is one of the non-invasive ways to rehabilitate and prevent complications and consequences of diseases related to Covid-19. The purpose of this study was to investigate the effect of moderate intensity aerobic exercise on the serum levels of interleukin-6, interleukin-10 and C-reactive protein in patients recovered from Covid-19.</span></span></span></span></div> <pre style="margin-top: 16px;"> <span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span courier="" new="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials </span></b><b><span new="" roman="" style="font-family:" times="">and Methods</span></b><b><span new="" roman="" style="font-family:" times="">:</span></b> <span new="" roman="" style="font-family:" times=""><span style="color:#202124">For this purpose, 24 men recovered from Covid-19 were voluntarily selected and placed in two groups of experimental (12 people) and control (12 people) in a simple random manner. The experimental group participated in an eight-week aerobic training program, three sessions per week, each session lasted about 40 to 55 minutes with an intensity equal to 60 to 80% of the maximum heart rate. Serum levels of IL-6, IL-10 and CRP (before and 48 hours after the protocol) were measured. The data was analyzed using the covariance statistical test (ANCOVA) at the (p<0.05) level.</span></span></span></span></span></span></pre> <div style="text-align: justify;"><span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b>Results:</b> The results showed that aerobic exercise did not lead to a significant change in the serum levels of IL-6 (p>0.05) and IL-10 (p>0.05) in the experimental group compared to the control group; however, it caused a significant decrease in the serum levels of CRP (p<0.05) in the experimental group. In addition, examining intra-group changes in IL-10 and CRP indicated that there is a significant change between the mean score before and after implementation of the protocol in the experimental group (p<0.05). While there was no significant difference between the before and after values in IL-6 (p<0.05).</span></span></span></span></span><br> <span style="font-size:10pt"><span style="background:white"><span style="text-justify:inter-ideograph"><span style="line-height:normal"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> Based on the results of this study, aerobic exercises can regulate and balance anti-inflammatory and inflammatory cytokines and adjust the amount of C-reactive protein through the recovery of physical fitness in patients who have recovered from Covid-19.</span></span></span></span></span></div> </td> </tr> </tbody> </table> </div> <div style="text-align: justify;"></div> کووید-19, اینترلوکین-6, اینترلوکین-10, CRP Covid-19, Interleukin-6, Interleukin-10, C-reactive protein 1393 1402 http://journal.jmu.ac.ir/browse.php?a_code=A-10-891-1&slc_lang=fa&sid=1 Davar Rezaeimanesh داور رضایی منش davarrezaee@yahoo.com 10031947532846007775 10031947532846007775 Yes Assistant Professor, Department of General Courses and Basic Sciences, the College of Economics and Management, Khorramshahr University of Marine Science and Technology, Khorramshahr, Iran استادیار، گروه عمومی و علوم پایه، دانشکده اقتصاد و مدیریت، دانشگاه علوم و فنون دریایی، خرمشهر، ایران Mohamad Kogani محمد کوگانی 10031947532846007776 10031947532846007776 No Research center for Environmental Contaminants (RCEC), Abadan Universiey of Medical sciences, Abadan, Iran مرکز تحقیقات آلاینده‌های محیطی، دانشگاه علوم پزشکی آبادان، آبادان، ایران