fa ارزیابی تأثیر مکمل ویتامین D3 بر اضطراب، افسردگی، کیفیت خواب و ناخوشی جسمی در دانشجویان دانشگاه علوم پزشکی کرمان علوم بهداشت / تغذیه Health Sciences / Nutrition پژوهشي Research <div style="text-align: justify;"></div> <div style="text-align: justify;"> <table align="left" cellpadding="0" cellspacing="0" hspace="0" vspace="0"> <tbody> <tr> <td style="padding-top:0in;padding-right:9.0pt;padding-bottom:0in;padding-left:9.0pt;vertical-align:top;"><strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مقدمه و هدف:</span></span></strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> افسردگی،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اضطراب</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اختلالات</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">خواب</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">از</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جمله</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مشکلات</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شایع</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جوامع</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">امروزی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به خصوص</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">میان</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">قشر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دانشجو</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">است و سطح</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ویتامین</span></span><span dir="LTR"> D₃ </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">با</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اختلالات</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ارتباط</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">می&shy; باشد. هدف</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">از</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">انجام</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مطالعه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ارزیابی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">تأثیر ویتامین</span></span><span dir="LTR"> D₃ </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بر</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اضطراب،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">افسردگی،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">کیفیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">خواب</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ناخوشی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جسمی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دانشجویان</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">است</span></span><span dir="LTR">.</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"></span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">روش کار:</span></span></strong> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">کارآزمایی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بالینی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دو</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">سویه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">کور،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">60</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دانشجو</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بدون بیماری زمینه &shy;ای</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شرکت کردند</span></span><span dir="LTR">.</span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">افراد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span><span dir="LTR">&shy;</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">صورت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">تصادفی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دو گروه</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مداخله (دریافت&shy; کننده ویتامین </span></span><span dir="LTR">&nbsp;(D₃</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و کنترل </span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">(دریافت کننده دارونما</span></span><span dir="LTR"> (</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">تقسیم</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شدند</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">.</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شرکت&shy; کنندگان</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> دو پرل 50000 واحدی ویتامین</span></span><span dir="LTR">D₃ </span>&nbsp;<span style="font-family:B Mitra;"><span style="font-size:12.0pt;">یا دارونما را در زمان آغاز مطالعه و بعد از 4 هفته دریافت کردند. کیفیت</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">خواب،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">اضطراب</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">افسردگی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و ناخوشی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">جسمی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">دانشجویان شرکت &shy;کننده</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">با</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">پرسشنامه&shy; های استاندارد </span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">مقیاس اضطراب و افسردگی بیمارستانی</span></span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">، کیفیت خواب پیتزبورگ و زیرمجموعه جسمانی&shy; سازی از چک &shy;لیست نشانگان اختلالات روانی،</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">قبل</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">از مداخله و 8</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">هفته</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بعد</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">ارزیابی</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">شد</span></span><span dir="LTR">.</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> تجزیه و تحلیل داده با نرم &shy;افزار</span></span><span dir="LTR">20 </span>&nbsp;<span dir="LTR">&nbsp;SPSS</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">و با استفاده از آزمون &shy;های تی مستقل، مجذور کای و تحلیل واریانس با مدل آمیخته انجام شد.</span></span><br> <strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">یافته&shy; ها:</span></span></strong> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">میانگین سنی دانشجویان شرکت &shy;کننده در این مطالعه 1/20</span></span><span dir="LTR">&plusmn;</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">23/12 سال بود. نتایج نشان&shy; داد که ویتامین </span></span><span dir="LTR">D₃</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> اثرات معنی&shy; داری از لحاظ آماری بر بهبود اضطراب (0/042</span></span><span dir="LTR">p= </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">)، افسردگی (0/001</span></span><span dir="LTR">p= </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">) و ناخوشی جسمی (0/0001</span></span><span dir="LTR">p= </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">) در دانشجویان در گروه درمان در مقایسه با گروه دارونما</span></span> <span style="font-family:B Mitra;"><span style="font-size:12.0pt;">بعد از 8 هفته داشت؛ ولی تأثیر قابل ‌ملاحظه‌ای بر کیفیت خواب (0/558</span></span><span dir="LTR">p= </span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">) ایجاد نکرد.</span></span> <strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"></span></span></strong><br> <strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;">نتیجه &shy;گیری:</span></span></strong><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> ویتامین </span></span><span dir="LTR">D₃</span><span style="font-family:B Mitra;"><span style="font-size:12.0pt;"> می&shy; تواند رابطه مستقیمی با افسردگی، اضطراب و ناخوشی جسمانی در دانشجویان داشته باشد، اما این نتایج برای تأیید به مطالعات بیشتری احتیاج دارند.</span></span></td> </tr> </tbody> </table> <div style="clear:both;"></div></div> <table align="center" cellpadding="0" cellspacing="0" hspace="0" vspace="0"> <tbody> <tr> <td style="text-align: justify;"><strong>Introduction:</strong> Depression, anxiety, and sleep disorders are common problems in today&#39;s societies, especially among students. Studies have shown that vitamin D₃ levels are associated with these disorders. The purpose of this study was to evaluate the effect of vitamin D3 supplementation on anxiety, depression, sleep quality and physical morbidity in university students.<br> <strong>Materials </strong><strong>and Methods</strong><strong>:</strong> In this double-blind clinical trial study, 60 students without underlying disease were participated. They were randomly divided into treatment group (receiving vitamin D3) and control group (receiving placebo). The participants received two 50000 IU pearls of vitamin D3 or placebo at baseline and after 4 weeks.&nbsp; Sleep quality, anxiety, depression, and physical morbidity of the participated students were evaluated by standardized questionnaires including Hospital Anxiety Depression Scale, Pittsburgh Sleep Quality Inventory and Somatization subscale of Symptom Checklist-90 before receiving vitamin D₃ and after 8 weeks. Data were analyzed using independent sample t-test, chi-square and mixed model analysis of variance in SPSS 20 software.<br> <strong>Results:</strong> The mean &plusmn; SD age of students who participated in this study was 23.12 &plusmn; 1.20 years. The results of this study showed that vitamin D₃ had statistically significant effects on improvement of anxiety (p=0.042), depression (p=0.001), and physical morbidity (p=0.0001) in university students in the treatment group in comparison with the placebo group after 8 weeks, but it did not have a significant effect (p=0.558) on students&#39; sleep quality.<br> <strong>Conclusion:</strong> The vitamin D3 could have direct relationship to depression, anxiety, and physical morbidity in university students, but these results need further studies to confirm.</td> </tr> </tbody> </table> <div style="text-align: justify;"><div style="clear:both;"></div></div> ویتامین D3 , اضطراب, افسردگی, خواب, ناخوشی Vitamin D3, Anxiety, Depression, Sleep, Morbidity 709 718 http://journal.jmu.ac.ir/browse.php?a_code=A-10-596-1&slc_lang=fa&sid=1 Somayeh Karami-Mohajeri سمیه کرمی مهاجری 10031947532846005530 10031947532846005530 No Assistant Professor, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran استادیار، گروه سم‌شناسی و داروشناسی، دانشکده داروسازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران Sepideh Khalifee سپیده خلیفه ای 10031947532846005531 10031947532846005531 No Pharm.D, Student research committee, Faculty of pharmacy, Kerman University of Medical Sciences, Kerman, Iran دکترای داروسازی، کمیته تحقیقات دانشجویی، دانشکده داروسازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران Mahmoud Reza Heidari محمود رضا حیدری 10031947532846005532 10031947532846005532 No Professor, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran استاد، مرکز تحقیقات فارماسیوتیکس، پژوهشکده نوروفارماکولوژی، دانشگاه علوم پزشکی کرمان، کرمان، ایران Fatemeh Dabaghzadeh فاطمه دباغ زاده dabaghzadeh@kmu.ac.ir 10031947532846005533 10031947532846005533 Yes Associate Professor, Department of Clinical Pharmacy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran دانشیار، گروه داروسازی بالینی، دانشکده داروسازی، دانشگاه علوم پزشکی کرمان، کرمان، ایران