Showing 7 results for Tavakoli
Somayeh Ahmadi, Elham Hakimizadeh, Hassanipour Mahsa, Abdolreza Kazemi, Mohammad Allahtavakoli,
Volume 6, Issue 2 (2-2020)
Abstract
Introduction: Exhaustive exercise leads to muscle fatigue and reduces muscle power in response to contractile activity and causes central fatigue. On the other hand, the effects of opioids on skeletal muscles and fatigue phenomenon are not known completely. Thus, the current study aimed to assess the effect of a single dose administration of opium on muscle and central fatigue in male rats.
Materials and Methods: In this experimental study, 21 male Wistar rats weighing 220-270 g were randomly divided into three equal groups: control, opium receiving group, opium without swimming (sham opium). In order to evaluate muscle fatigue, swimming test was used and for central fatigue the sedation score was used. At the end of the experiments, blood samples were obtained from animal eyes and were sent to the laboratory for measurement of muscle fatigue indices including lactate dehydrogenase (LDH) and creatine phosphokinase (CPK). Data were analyzed using ANOVA, T-test and SPSS software.
Results: Data showed that the swimming time in animals receiving opium was significantly lower than control group (P<0.001). Data also revealed that central fatigue in opium group was significantly lower than control animals (P<0.001). Moreover, opium alone and without swimming test caused central fatigue in animals (P<0.05).
Conclusion: The present study showed that administration of a single dose of opium in rat’s increases muscle fatigue. Moreover, opium administration reduced central fatigue in rats. |
Mohammad Allahtavakoli,
Volume 7, Issue 1 (3-2020)
Abstract
در حال حاضر ویروس COVID_19 (بیماری کرونا) که در بعضی از مبتلایان منجر به سندرم زجر تنفسی شدید و حاد(ARDS- Acute Respiratory Distress Syndrome) شده و ممکن است منجر به مرگ برخی بیماران نیز گردد، پاندمیک (Pandemic) یا جهانگیر شده و در حال گسترش در همه کشورها است (1). عدم وجود هرگونه درمان یا پیشگیری قطعی و پیشبینی برخی از اپیدمیولوژیستها در خصوص ابتلای حداقل 60% جامعه به این بیماری، استرس و نگرانی زیادی را در جوامع ایجاد کردهاست (2).
ترس و اضطراب ناشی از ابتلای احتمالی، مخرب بوده و میتواند منجر به ناهنجاریهای روحی روانی و استرس در افراد شود. ترس و استرس با تحریک هیپوتالاموس در مغز و به‌دنبال آن افزایش ترشح هورمون کورتیزول از قشر غده فوق کلیه و تحریک اعصاب سمپاتیک در سراسر بدن در کوتاهمدت برای مقابله بدن با عوامل استرسزا سودمند است (3). اما اگر این ترس و استرس و پاسخ بدن یعنی افزایش سطح کورتیزول و تحریک سمپاتیک در درازمدت باقی بماند، مخرب بوده و منجر به تضعیف سیستم ایمنی و کاهش توان بدن در مبارزه با بیماریها از جمله کرونا می‌شود (4). بنابراین، مقابله با استرس جامعه را در برابر بیماری مقاوم می‌کند.
اقدامات متعددی جهت حمایت از خود و کاهش استرس وجود دارد که از جمله آن میتوان به فاصله گرفتن از تماشا، شنیدن و یا خواندن اخبار تکراری بیماری کرونا از طریق رسانه های اجتماعی اشاره نمود. شنیدن مکرر اخبار در مورد گسترش این بیماری در ایران و جهان استرس آور بوده و ترس و نگرانی را بیشتر دامن می‌زند.
در زمانی که در قرنطینه خانگی به سر میبریم، مراقبت از بدن خود با کنترل استرس اهمیت دوچندان پیدا می‌کند. تکنیکهای آرام سازی، نفس کشیدن عمیق آگاهانه، ورزشهای کششی مانند یوگا بسیار توصیه می‌شوند که در مورد انجام هرکدام از آنها با جستجو در مرورگرهایی مانند گوگل میتوان اطلاعات کاملی بدست آورد. همچنین، تغذیه سالم و تعادل در رژیم غذایی، ورزش منظم (ترجیحاً در داخل منزل مانند استفاده از تردمیل، طناب زدن، وزنه برداری متعادل و یا راه رفتن تند در حیاط)، خواب و استراحت کافی، و نهایتاً عدم مصرف مخدرها یا الکل از مهمترین راههای مراقبت از بدن است. بهتر است وقت خود را صرف فعالیتهای لذت بخش نمود. خواندن کتاب و رمان، تمرین یک ساز موسیقی، بافندگی و دوزندگی از جمله این فعالیتها است. در پایان، برقرای ارتباط از طریق رسانه‌های اجتماعی با افرادی که مورد اعتماد ما هستند و صحبت در مورد نگرانیها و احساساتی که داریم، بسیار کمک کننده است.
Mohadeseh Mohammadi, Ali Shamsi Zadeh, Mohammadreza Rahmani, Ayat Kaeidi, Jalal Hasan Shahi, Gholamreza Bazmandegan, Elham Hakimizadeh, Amir Moghadam Ahmadi, Mohammad Allahtavakoli,
Volume 7, Issue 2 (6-2020)
Abstract
Introduction: Stroke is a neurological disease and one of the leading causes of death all over the world. It is also an important cause of disability in people over age over 65. It may be possible to reduce the incidence of cerebral ischemia using antioxidants, followed by inhibition of oxidative and inflammatory mechanisms. Troxerutin is a natural bioflavonoid with antioxidant and anti-inflammatory properties. However, its neuroprotective effects have not yet been studied. The present study aimed to investigate the effect of troxerutin on ischemic brain damage in male mice.
Materials and Methods: In this experimental study, 39 male mice (30-25 grams) were used. The animals were divided into three groups: 1. Sham group 2. Ischemic brain group 3. The ischemic brain group, receiving troxerutin drug. Cerebral ischemia was induced in the second and third groups of mice. Five hours later, group 3 received 300 mg/kg troxerutin intraperitoneal injection. After 24 and 48 hours, the effect of troxerutin on sensory and motor neurological disorders, cerebral edema, and infarct volume was investigated. Analysis of variance test was performed by SPSS software (21) using one-way and two-way.
Results: The results indicated that troxerutin reduced stroke volume (p=0.05) and cerebral edema (p=0.05) compared with the control group. Troxerutin also improved sensory-motor function (p<0.0001) and balance function and muscle strength (p<0.05)
Conclusion: Treatment with troxerutin can have beneficial effects on complications and disorders caused by cerebral ischemia. |
Pooya Saeed Askari, Iman Fatemi, Elham Hakimizadeh, Ayat Kaeidi, Sogand Esmaeil Moghaddam, Mohammad Pak-Hashemi, Mohammad Allahtavakoli,
Volume 7, Issue 3 (10-2020)
Abstract
Introduction: Metformin (MET) as an oral antidiabetic drug has pleiotropic effects such as antioxidative and neuroprotective properties. In the current study we aimed to investigate the probable effects of Pretreatment MET therapy in global ischemia-reperfusion in rats.
Materials and Methods: In this study, 40 male Wistar rats (200-220 g) were used. Animals were randomly divided into four groups of ten: sham group, ischemic group, ischemic + metformin group and metformin group. MET was administered orally at doses of 100 for 14 days then the rats underwent global ischemia-reperfusion and the treatment continued for 7 days. Depressive-like behavior was assessed by forced swimming test. Cognitive function was evaluated by Y-maze continuous alternation task and Morris water maze. The brains were assessed for the activity of superoxide dismutase (SOD) as well as level of brain-derived neurotrophic factor (BDNF).
Results: global ischemia-reperfusion caused depression and declined the cognitive function (p<0.001( as well as BDNF (p<0.001( level and SOD (p<0.01 (activity. Pretreatment with MET reduced the depressive-like behavior (p<0.05( and attenuated the cognitive impairments (p<0.01( in ischemic rats. Moreover, MET increased the BDNF (p<0.001( level in the brains of ischemic animals
Conclusion: Our results recommended that chronic pretreatment MET therapy could improve behavioral disorders following global ischemia-reperfusion and could be used as a novel therapeutic approach for the treatment of brain ischemic conditions. |
Neda Dastyar, Nasibeh Salari, Sudabeh Ahmadi, Foozieh Rafati, Saadat Salari, Bahareh Tavakoli,
Volume 9, Issue 1 (5-2022)
Abstract
Abbas Bayat Asghari, Javad Javaheri, Alireza Manzari Tavakoli, Hamid Mollayi Zarandi,
Volume 9, Issue 3 (12-2022)
Abstract
Introduction: Divorce is one of the most important social phenomena that depends on many factors. The purpose of this study was to compare the effectiveness of cognitive-behavioral therapy and motivational interviewing on symptoms of anxiety sensitivity in divorced women.
Materials and Methods: The current study was a quasi-experimental interventional design. The statistical population consisted of 260 divorced women aged 20 to 50. Sixty of the mentioned women were selected based on the inclusion criteria and randomly assign to three groups, cognitive-behavioral therapy, motivational interview therapy, and control group. The instrument of data collection was Reyes and Patterson's Anxiety Sensitivity Questionnaire. For the experimental groups, 12 sessions of 75 minutes were held. No intervention was done for the control group. Before the interventions and at the end of the study, people in all groups filled out the anxiety sensitivity questionnaire. The data was analyzed using SPSS version 25 software and analysis of covariance (ANCOVA).
Results: There was a significant difference in the mean score of the anxiety sensitivity variable between the three groups of cognitive-behavioral therapy, motivational interviewing and the control group (p<0.05). Also, in the one-by-one comparison of the cognitive-behavioral therapy and motivational interview therapy groups with the control group, there was a significant difference in the post-test stage (p<0.05).
Conclusion: The findings indicate that the methods of cognitive-behavioral therapy and motivational interviewing are effective in reducing anxiety sensitivity in divorced women. It is suggested to use these two methods along with other psychological and pharmacological interventions in order to reduce anxiety sensitivity in divorced women as a clinical intervention. |
Neda Dastyar, Sudabeh Ahmadidarrehsima, Foozieh Rafati, Saadat Salari, Bahareh Tavakoli, Nasibeh Salari,
Volume 9, Issue 4 (3-2023)
Abstract
Introduction: Considering the growing trend of the elderly population and the need to assess their health status, the present study was conducted with the aim of comparing high blood pressure, diabetes, depression and the possibility of falling in elderly men and women in the south of Kerman in the years 2017 to 2019.
Materials and Methods: This descriptive (cross-sectional) study was conducted on the health information of people aged over 60 years (56,800 people) who registered in the integrated health system (Sib system). Data were analyzed using SPSS version 16 software and chi-square test.
Results: The results showed that in the studied men and women in 2019, 2018 and 2017 respectively, the rate of high blood pressure was 8,053 (%26.3), 7,700 (%26.94) and 7,814 (%29.6) respectively. In the years 2019, 2018 and 2017, the incidence of diabetes was 7,456 (%22.5), 7,083 (%24.5) and 7,253 (%26) in women and men, respectively. The percentage of elderly women suffering from depression was higher than that of men, and the total percentage of falling probability of elderly women and men during different years was more than 50%. The prevalence of high blood pressure, diabetes, depression, and the possibility of falling had a significant relationship with gender (p<0.001).
Conclusion: The percentage of high blood pressure, diabetes, depression and the probability of falling in the studied elderly women was higher than that of men. Therefore, the monitoring of these indicators and preventive interventions should be given more attention. |
