Introduction: Along with increasing antifungal resistance in recent years, using novel antifungal compounds have been extended considerably caused researchers have been investigated new antifungal compounds. Thiazole derivatives and silver nanoparticles are chemical compounds with antifungal effects which have attracted researchers recently. In this study the inhibitory effects of four thiazole-thiazolidine derivatives were studied on Aspergillus niger, Candida albicans and Fusarium solani.

Methods: In this study, at first, thiazole derivatives and silver nanoparticles were prepared as a solution. Then disk diffusion three times was used for calculation of growth inhibition zone diameters and serial dilution method in microplates was used to assess minimum inhibitory concentrations (MICs) for three times in-vitro.          

Results: Results showed that 6a-c thiazole derivatives and silver nanoparticles had no significant inhibitory effects on all of the fungi, but growth inhibition zone diameters and MIC were reported 16 mm and 64 µg/ml for 6d thiazole derivative on Aspergillus niger.

Conclusion: In this study only existing of thiazole ring don’t have inhibition effects but the inhibitory effects of these compounds depend on cross linking to this ring; for example connection of oxygen to thiazole ring in 6d derivative is a proof to this claim, and also diameter and number in silver nanoparticles have important role in antifungal effect.

Key word: Antifungal effect, thiazole derivative, silver nanoparticle