Volume 9, Issue 1 (5-2022)                   J Jiroft Univ Med Sci 2022, 9(1): 915-923 | Back to browse issues page

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Azizi Ghouchan Z, Ravasi A A, Delfan M. The Effect of High Intensity Interval Training on the Gene Expression of Adiponectin and Resistin in Adipose Tissue of Diabetic Rats. J Jiroft Univ Med Sci. 2022; 9 (1) :915-923
URL: http://journal.jmu.ac.ir/article-1-594-en.html
1- Phd Student in Sport Physiology, Alborz Campus, University of Tehran, Tehran, Iran
2- Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tehran, Tehran, Iran , aaravasi@ut.ac.ir
3- Assistant Professor Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran
Abstract:   (163 Views)
Introduction: Moderate volume interval training regulates gene expression in patients with diabetes and reduces the risks of hyperglycemia. The aim of this study was to evaluate the eeffects of high intensity interval Training on the gene expression of Adiponectin and Resistin in adipose tissue of diabetic Rats.
Materials and Methods: The present study was experimental. To this end, 24 diabetic male Wistar rats were divided into three groups (n-8); normal control (NC), diabetic control (DC), high intensity interval training (HIIT). Diabetes was induced in all groups expect for normal control group by intraperitoneal streptozotocin injection after 12 hours of fasting. Glucose oxidase was used to measure glucose in plasma using ELISA method to measure insulin levels.HOMA-IR method was used to measure insulin resistance index. Real-time PCR technique was used to evaluate the gene expression of the Adiponectin and Resistin. Comparison of groups was performed by (one way ANOVA) at the alpha level of 0.05.
Results: Adiponectin gene expression was significantly increased in HIIT group compared to DC group (p<0.05). Resistance gene expression in HIIT group was significantly reduced compared to DC group (p≤0.001). Insulin resistance was significantly reduced in the HIIT group.
Conclusion: The results showed that intense intermittent exercise reduced insulin resistance and possibly regulated cellular metabolism by increasing adiponectin gene expression and decreasing resistin gene.
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Type of Study: Research | Subject: Medical Sciences / Sports Medicine
Received: 2022/03/14 | Accepted: 2022/06/19 | Published: 2022/06/21

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