Volume 7, Issue 4 (1-2021)                   J Jiroft Univ Med Sci 2021, 7(4): 525-531 | Back to browse issues page

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1- . Assistant professor, Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
2- Undergraduate Student of Dentistry, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
3- Assistant Professor, Department of Pathology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
4- Professor, School of Dentistry, Rafsanjan University of Medical Science, Rafsanjan, Iran
5- Assistant Professor, Department of Periodontology Dentistry, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran , ssalarisedigh@gmail.com
6- . Assistant Professor of Physiology, Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, School of Medicine Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Abstract:   (334 Views)
Introduction: As, copper sulfate acts as an enzyme cofactors, it can affect oral tissues. Therefore, this study aimed to evaluate the effect of copper sulfate on soft and hard oral tissues.
Materials and Methods: This animal study was conducted on 14 male rats (200-250 gr). The rats were divided into two groups of treatment and control. The treatment group received oral copper sulfate in 80 days. The rats were anesthetized and blood samples were taken from their hearts. Then, their tongue and jaw were also removed for microscopic examination. Liver serum enzymes were measured. Tissue samples were examined for inflammation, number of blood vessels per unit area, percentage of fibrotic tissue, necrosis, mucosal ulcer, atrophy, and superficial epithelial hyperplasia, bleeding and pulp calcification. Data were analyzed by SPSS 22 using independent t-test (p<0.05).
Results: AST and ALT enzymes showed significant differences, but the ALP enzyme did not show any significant difference. The number of blood vessels in the gums and tongue showed a significant difference. Inflammation, fibroticization, necrosis, mucosal ulceration, hemorrhage, atrophy, and superficial epithelial hyperplasia and pulp calcification were not found in any of the tongue and jaw specimens.
Conclusion: Copper sulfate intoxication increased the amount of angiogenesis in the oral tissues and it had no role in inflammation, hemorrhage, atrophy or epithelial ulcer, fibrotic tissue, necrosis and pulp calcification.
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Type of Study: Research | Subject: Medical Sciences / Physiology
Received: 2020/07/11 | Accepted: 2021/01/23 | Published: 2021/01/25

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