RT - Journal Article T1 - The effect of 4 weeks of aerobic training and octapamine on the levels of malondialdehyde and caspase 3 in brown adipose tissue in rats received deeply heated oils treatment JF - JJUMS YR - 2020 JO - JJUMS VO - 7 IS - 2 UR - http://journal.jmu.ac.ir/article-1-374-en.html SP - 394 EP - 403 K1 - Apoptosis K1 - Oxidative Stress K1 - Actapamine K1 - Aerobic Exercise K1 - Heated Oil AB - Introduction: Deep heated oils produce toxins which endanger people's health. Octopamine as an antioxidant supplement and aerobic exercise as a practical method can also improve health. The aim of this study was to investigate the effect of 4 weeks of aerobic and octapamine training on the amount of malondialdehyde and caspase 3 in the brown adipose tissue of male rats fed with deep heated oils. Materials and Methods: In one experimental trial of 40 male Wistar rats after four weeks being feed with heated oil in five groups of 8, were selected as a statistical sample and randomly divided into groups: control-poisoning, exercise-poisoning, supplement-poisoning, Supplement-Exercise-Poisoning and Control-Health were divided. The 4 week training program, with 50 to 65 percent vo2max intensity on the treadmill, was three sessions a week for 20 minutes. Octopamine was used as a supplement for 4 weeks and 5 days a week using a dose of 81 μmol / kg as an intraperitoneal injection. ELISA Assay and Caspase 3 IHC immunohistochemistry were used to evaluate malondialdehyde Results: Due to deep-poisoned oil poisoning, the concentration of malondialdehyde increased significantly (p<0.001). Exercise significantly reduced the concentration of malondialdehyde (p<0.001). Ectapamine supplementation also reduced the concentration of malondialdehyde (p<0.001). The interaction of octapamine training and supplementation was also significant and decreased malondialdehyde concentration (p<0.05). Aerobic exercise had a significant effect on Caspase 3 concentration (p<0.001). Intake of octopamine supplementation also had a significant effect on Caspase 3 concentration (p<0.001). The interaction of aerobic exercise and octopamine also significantly reduced caspase 3 (p<0.05). Conclusion: Aerobic exercise and octopamine reduce the destructive effects of deeply heated oils. Octopamine as an antioxidant and aerobic exercise as an important factor maintains the structure and function of brown adipose tissue. LA eng UL http://journal.jmu.ac.ir/article-1-374-en.html M3 ER -