Volume 9, Issue 1 (5-2022)                   J Jiroft Univ Med Sci 2022, 9(1): 842-852 | Back to browse issues page

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Kalantar H, Goudarzi M, Khodayar M J, Sadeghi E, Basir Z, Haghi Karamallah M et al . Protective Effects of Berberine on Bromobenzene-Induced Nephrotoxicity in Mice. J Jiroft Univ Med Sci 2022; 9 (1) :842-852
URL: http://journal.jmu.ac.ir/article-1-577-en.html
1- Assistant professor, Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Assistant professor, Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Associate Professor, Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Doctor of Pharmacy, Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Assistant professor, Depatment of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
6- Assistant professor, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
7- Assistant professor, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran , Kalantar-m@shoushtarums.ac.ir
Abstract:   (423 Views)
Introduction: Bromobenzene is an environmental toxin whose metabolites cause renal toxicity. The mechanism involved in toxicity includes oxidative stress. The aim of this study was to investigate the protective effects of berberine against bromobenzene-induced renal toxicity in male NMRI mice.
Materials and Methods: In this experimental study, subjects were divided into five groups. Group I: control: recipient of normal salineGroup II: recipient of bromobenzene at a dose of 0.36 ml/kg intraperitoneally on the tenth day. Third, fourth and fifth groups: recipient of berberine at doses of 25, 50, 100 mg/kg, orally for 10 days successively, and bromobenzene at a dose of 0.36 ml/kg intraperitoneally. 24 hours after the last administration, blood samples were taken from animals and renal markers were measured. The right kidney was used to measure markers of oxidative stress and the left kidney was used for histological studies.
Results: The results of this study revealed that bromobenzene administration causes a significant increase in blood urea nitrogen creatinine, malondialdehyde and nitric oxide, as well as a significant reduction of glutathione levels and activity of catalase, superoxide dismutase and glutathione peroxidase enzymes than the control group (p<0.05). But berberine causes a significant decrease in blood urea nitrogen creatinine, malondialdehyde and nitric oxide, as well as a significant increase of glutathione levels and activity of catalase, superoxide dismutase and glutathione peroxidase enzymes than the bromobenzene group (p<0.05).
Conclusion: The present study indicates that treatment with berberine significantly improved renal function and reduced oxidative damage to kidney tissue in bromobenzene-induced toxicity.
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Type of Study: Research | Subject: Medical Sciences / Pharmacology
Received: 2022/02/1 | Accepted: 2022/04/18 | Published: 2022/06/20

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