Volume 8, Issue 4 (3-2022)                   J Jiroft Univ Med Sci 2022, 8(4): 799-808 | Back to browse issues page

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Protective effects of hydroalcoholic extract of the aerial parts of Alcea rosea on serum lipid concentration disorders in male rats exposed to cadmium chloride
Mernosh Ghavami , Mehrdad Shariati1 , Davood Moghadamnia 2
1- Associate Professor, Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
2- Ph.D in Animal Physiology, Department of Biology, Shiraz Branch, Islamic Azad University Shiraz, Iran , davood.moghadamnia@gmail.com
Abstract:   (1015 Views)
Introduction: Alcea rosea is on the list of medicinal plants with the potential for a serum lipid-lowering effect in patients with lipid disorder. Cadmium chloride causes lipid disorders. This study investigated the protective effects of hydroalcoholic extract of the aerial parts of Alcea rosea on serum lipid concentration disorders in male rats exposed to cadmium chloride
Materials and Methods: In this experimental study, 54 adult male Wistar rats were divided into 6 groups of 9. The control group, the sham group1 received 0.2 ml /kg distilled water as solvent. The sham group2 received 2 mg / kg cadmium chloride intraperitoneally for 21 days. Experimental groups 1, 2 and 3 respectively, received 2 mg / kg cadmium chloride intraperitoneally for 21 days and then 150, 300, and 450 mg / kg hydroalcoholic extracts of the aerial parts of Alcea rosea intraperitoneally for 30 days. Blood samples were taken from all animals at the end of the experiment to measure levels of HDL, LDL, total cholesterol and triglycerides. Data were analyzed through SPSS18 program, ANOVA and Tukey tests.
Results: The mean serum concentrations of total cholesterol, triglyceride, and LDL cholesterol in all experimental groups compared to the sham group2 revealed a significant decrease. Mean serum HDL cholesterol concentration in experimental groups 3 also showed a significant increase compared to the sham group2 (p<0.05).
Conclusion: The hydroalcoholic extract of the aerial parts of Alcea rosea probably improves the lipid disorders caused by cadmium chloride in male rats.
Keywords: Alcea rosea, Cadmium chloride, Lipid disorders, Male rats
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Type of Study: Research | Subject: Medical Sciences / Physiology
Received: 2021/12/18 | Accepted: 2022/02/19 | Published: 2022/03/1
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