Volume 8, Issue 3 (12-2021)                   J Jiroft Univ Med Sci 2021, 8(3): 690-698 | Back to browse issues page

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Shirani M, Mahdavinia M, khoshnood S, Kalantari H, Raesi Vanani A. Study of anti-yeast effects of Securigera Securidaca (L.) extracts microemulsion on Candida strains. J Jiroft Univ Med Sci. 2021; 8 (3) :690-698
URL: http://journal.jmu.ac.ir/article-1-515-en.html
1- Assistant Professor, Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Medical Sciences, Ahvaz, Iran
2- Assistant Professor, Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , mahdavimasoud@yahoo.com
3- Assistant Professor, Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
4- Professor, Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- PhD in Toxicology, Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (261 Views)
Introduction: Candida infections constitute a large group of diseases, so today the need for low-harm antifungal agents is felt more than ever. Securigera Securidaca L. is a medicinal plant with antimicrobial, anti-pest, anti-parasitic and anti-fungal properties. Therefore, the aim of this study was to determine the anti-candida effects of microemulsion of ethanolic and methanolic extracts of Securigera Securidaca on different strains of Candida.
Materials and Methods: In this laboratory study, ethanolic and methanolic extracts of Securigera Securidaca and twin 80 were used to make microemulsions. After examining the physicochemical characteristics (viscosity and pH), the well diffusion method was used to investigate the anti-yeast effect of the formulation on Candida strains.
Results: Microemulsions in concentrations of 0.01% of Securigera Securidaca extracts showed significant anti-candidal properties. These microemulsions had the highest inhibitory effect against Candida albicans.
Conclusion: Synthesized microemulsions based on Securigera Securidaca plant extract have good stability and showed high anti-yeast properties against Candida strains.
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Type of Study: Research | Subject: Medical Sciences / Microbiology
Received: 2021/07/26 | Accepted: 2021/10/18 | Published: 2021/10/22

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