Volume 8, Issue 2 (7-2021)
J Jiroft Univ Med Sci 2021, 8(2): 674-682 |
Back to browse issues page
1- Ph.D, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Professor, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m.peeri@iauctb.ac.ir
3- Professor, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
2- Professor, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , m.peeri@iauctb.ac.ir
3- Professor, Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran
Abstract: (1525 Views)
| Introduction: Cardiovascular disease is the leading cause of death in today's society, the main causes of which are a sedentary lifestyle and the use of high-fat and unbalanced diets. The aim of this study was to determine the effect of 4 weeks of aerobic exercise with octapamine supplementation on NLRP-3 gene expression and TRK-β protein synthesis in the heart muscle of rats fed with deep-fried oil. Materials and Methods: 30 male Wistar rats weighing 200-250 were randomly divided into 5 groups of 6: health control (CO), deep-fried oil (I), deep-fried oil + aerobic exercise (H), deep-fried oil + octapamine, supplementation (B), and deep-fried oil + octapamine supplementation + aerobic exercise (C). During the research period, 10 ml/kg deep-fried oil was given to the rats via gavage for 4 weeks. 81 mol/kg octapamine was intraperitoneally injected to the supplement groups. The rats in the exercise group also went through moderate intensity training in the first week (50% vo2max) and last week (65% vo2max) with treadmill. One way analysis of variance was used to analyze the data and Bonferroni test was used to determine the difference, using Graph pad prism version 8. Results: NLRP-3 gene expression was significantly reduced in the exercise group compared to the control group who did not receive any supplements and exercise (p<0.05). Octapamine supplementation also decreased NLRP-3 (p<0.05). The combination of exercise and supplementation significantly reduced NLRP-3 gene expression compared with the control group (p<0.05). Changes in the amount of TRK-β protein in the exercise group did not show a significant difference compared to the control group that did not receive any supplements and exercise (p>0.05). In the group that also received octapamine supplementation, compared to the control group, TRK-β values did not change and did not show a significant difference (p>0.05). Combining exercise and supplementation significantly increased TRK-β gene expression compared to the exercise group (p<0.05). Conclusion: Aerobic exercise training with octapamine supplementation may reduce the destructive effects of deep-heated oils on the expression of the gene associated with myocardial degradation and improve remodeling in myocytes. |
Type of Study: Research |
Subject:
Medical Sciences / Physiology
Received: 2021/06/27 | Accepted: 2021/09/11 | Published: 2021/09/20
Received: 2021/06/27 | Accepted: 2021/09/11 | Published: 2021/09/20
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |